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Miniature of Using metabolic oligosaccharide engineering to induce immune-mediated cell killing of bacterial pathogens
Using metabolic oligosaccharide engineering to induce immune-mediated cell killing of bacterial pathogens
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      Date: 2020-01-01

      Creator: Brendan H. Pulsifer

      Access: Access restricted to the Bowdoin Community

        Miniature of Dismantling the bacterial glycocalyx: Chemical tools to probe, perturb, and image bacterial glycans
        Dismantling the bacterial glycocalyx: Chemical tools to probe, perturb, and image bacterial glycans

        Date: 2021-07-15

        Creator: Phuong Luong, Danielle H. Dube

        Access: Open access

        The bacterial glycocalyx is a quintessential drug target comprised of structurally distinct glycans. Bacterial glycans bear unusual monosaccharide building blocks whose proper construction is critical for bacterial fitness, survival, and colonization in the human host. Despite their appeal as therapeutic targets, bacterial glycans are difficult to study due to the presence of rare bacterial monosaccharides that are linked and modified in atypical manners. Their structural complexity ultimately hampers their analytical characterization. This review highlights recent advances in bacterial chemical glycobiology and focuses on the development of chemical tools to probe, perturb, and image bacterial glycans and their biosynthesis. Current technologies have enabled the study of bacterial glycosylation machinery even in the absence of detailed structural information.