Showing 951 - 960 of 5714 Items
Dismantling the bacterial glycocalyx: Chemical tools to probe, perturb, and image bacterial glycans
Date: 2021-07-15
Creator: Phuong Luong, Danielle H. Dube
Access: Open access
- The bacterial glycocalyx is a quintessential drug target comprised of structurally distinct glycans. Bacterial glycans bear unusual monosaccharide building blocks whose proper construction is critical for bacterial fitness, survival, and colonization in the human host. Despite their appeal as therapeutic targets, bacterial glycans are difficult to study due to the presence of rare bacterial monosaccharides that are linked and modified in atypical manners. Their structural complexity ultimately hampers their analytical characterization. This review highlights recent advances in bacterial chemical glycobiology and focuses on the development of chemical tools to probe, perturb, and image bacterial glycans and their biosynthesis. Current technologies have enabled the study of bacterial glycosylation machinery even in the absence of detailed structural information.
Bowdoin Sculpture of St. John Nepomuk
Date: 1975-01-01
Creator: Zdenka Volavka
Access: Open access
- "Composition by the Anthoensen Press, Portland, Maine"--P. [2]
Joseph Nicoletti: Paintings and Drawings
Date: 1977-01-01
Access: Open access
- Catalog of the exhibition held Jan. 21-Feb. 27, 1977.
Catalogue of the Bowdoin Collection of Paintings, Bowdoin College
Date: 1870-01-01
Access: Open access
- "Note" signed: J.B.S
French Impressionist and Post Impressionist Paintings from the Collections of Mrs. Bertha Palmer Thorne and Mr. Gordon Palmer
Date: 1962-01-01
Access: Open access
- Handlist of an exhibition held at the Walker Art Museum, Bowdoin College, Brunswick, Maine, May 11-June 17, 1962.
Post-translational modification directs nuclear and hyphal tip localization of Candida albicans mRNA-binding protein Slr1
Date: 2017-05-01
Creator: Chaiyaboot Ariyachet, Christian Beißel, Xiang Li, Selena Lorrey, Olivia, Mackenzie, Patrick M. Martin, Katharine O'Brien, Tossapol Pholcharee, Sue Sim, Heike Krebber, Anne E. McBride
Access: Open access
- The morphological transition of the opportunistic fungal pathogen Candida albicans from budding to hyphal growth has been implicated in its ability to cause disease in animal models. Absence of SR-like RNA-binding protein Slr1 slows hyphal formation and decreases virulence in a systemic candidiasis model, suggesting a role for post-transcriptional regulation in these processes. SR (serine–arginine)-rich proteins influence multiple steps in mRNA metabolism and their localization and function are frequently controlled by modification. We now demonstrate that Slr1 binds to polyadenylated RNA and that its intracellular localization is modulated by phosphorylation and methylation. Wildtype Slr1-GFP is predominantly nuclear, but also co-fractionates with translating ribosomes. The non-phosphorylatable slr1-6SA-GFP protein, in which six serines in SR/RS clusters are substituted with alanines, primarily localizes to the cytoplasm in budding cells. Intriguingly, hyphal cells display a slr1-6SA-GFP focus at the tip near the Spitzenkörper, a vesicular structure involved in molecular trafficking to the tip. The presence of slr1-6SA-GFP hyphal tip foci is reduced in the absence of the mRNA-transport protein She3, suggesting that unphosphorylated Slr1 associates with mRNA–protein complexes transported to the tip. The impact of SLR1 deletion on hyphal formation and function thus may be partially due to a role in hyphal mRNA transport.
Textures of Our Earth: Bayetage Tapestries by Nancy Hemenway: 1972-1977
Date: 1977-01-01
Creator: Benjamin Forgery
Access: Open access
- Catalogue of an exhibition organized by the Bowdoin College Museum of Art; participating museums: Bowdoin College Museum of Art, Aug. 5-Sept. 25, 1977; Virginia Museum of Fine Arts, Oct. 18-Nov. 20, 1977; Seattle Art Museum, May 18-June 25, 1978; Textile Museum, Sept. 15-Oct. 28, 1978.
The Impact of Ride-Hailing Services on Public Transportation Use: A Discontinuity Regression Analysis
Date: 2017-05-26
Creator: Nicole Sadowsky, Erik Nelson
Access: Open access
- Since 2011, the private ride-hailing companies Uber and Lyft have expanded into more and more US cities. We use regression discontinuity design to examine the impact of Uber and Lyft’s entry on public transportation use in the US’ largest urban areas. In most cases, entry into cities by the two ride-hailing companies was staggered: Uber entered first followed some months later by Lyft. We find that public transportation use increased in an urban area, all else equal, immediately following the first entry. However, we find that the spike in public transportation use after first entry disappeared following the entry of the second company. In fact there is some evidence that monthly public transportation ridership levels fell below their pre-first entry levels. In other words, the joint presence of the two major private ride-hailing services transformed ride-hailing services from a public transportation complement to a public transportation substitute, at least in the studied urban areas. We speculate that the first entrant complemented public transportation use for some in an urban area by solving the “last-mile” problem and by providing a potentially safer option at night when public transportation service has been reduced. However, we speculate the second entrant is likely to have spurred price competition in the urban area’s ride-hailing duopoly market and an increase in ride-hailing car supply. This competitive effect could have tipped the scales, making an entire trip with a ride-hailing service more cost-effective and convenient than splitting a trip between a ride-share company and public transportation.
A new global ethic»: A history of the United Nations International Environmental Education Program, 1975-1995
Date: 2020-12-01
Creator: Charles Dorn
Access: Open access
- In 1975, the United Nations, under the auspices of its Educational, Scientific and Cultural Organization (UNESCO) and Environment Program (UNEP), established the International Environmental Education Program (IEEP). For two decades, IEEP aimed to accomplish goals ascribed to it by UNESCO member states and fostered communication across the international community through Connect, the UNESCO-UNEP environmental education newsletter. After reviewing UNESCO’s early involvement with the environment, this study examines IEEP’s development, beginning with its conceptual grounding in the 1968 UNESCO Biosphere Conference. It examines the 1972 United Nations Conference on the Human Environment held in Stockholm, moves on to the UNESCO-UNEP 1975 Belgrade Workshop, and continues with the world’s first intergovernmental conference dedicated to environmental education held in Tbilisi in 1977. The paper then uses Connect to trace changes in the form and content of environmental education. Across two decades, environmental education shifted from providing instruction about nature protection and natural resource conservation to fostering an environmental ethic through a problems-based, interdisciplinary study of the ecology of the total environment to adopting the concept of sustainable development. IEEP ultimately met with mixed success. Yet it was the primary United Nations program assigned the task of creating and implementing environmental education globally and thus offers a particularly useful lens through which to analyze changes in the international community’s understanding of the concept of the environment over time.
State of the Arg: Protein methylation at arginine comes of age
Date: 2001-07-13
Creator: Anne E. McBride, Pamela A. Silver
Access: Open access