Showing 631 - 640 of 2040 Items

Bowdoin College Catalogue (2009-2010)

Date: 2010-01-01

Access: Open access



Bowdoin College Catalogue (1989-1990)

Date: 1990-01-01

Access: Open access



Bowdoin College Catalogue (1988-1989)

Date: 1989-01-01

Access: Open access



Bowdoin College Catalogue (1987-1988)

Date: 1988-01-01

Access: Open access



Bowdoin College Catalogue (1980-1981)

Date: 1981-01-01

Access: Open access



Bowdoin College Catalogue (1835 Apr)

Date: 1835-04-01

Access: Open access



Bowdoin College Catalogue (2013-2014)

Date: 2014-01-01

Access: Open access



Bowdoin College Catalogue (2011-2012)

Date: 2012-01-01

Access: Open access



Demonstration of loss of heterozygosity by single-nucleotide polymorphism microarray analysis and alterations in strain morphology in Candida albicans strains during infection

Date: 2005-01-01

Creator: Anja Forche

Georgiana May

P. T. Magee

Access: Open access

Candida albicans is a diploid yeast with a predominantly clonal mode of reproduction, and no complete sexual cycle is known. As a commensal organism, it inhabits a variety of niches in humans. It becomes an opportunistic pathogen in immunocompromised patients and can cause both superficial and disseminated infections. It has been demonstrated that genome rearrangement and genetic variation in isolates of C. albicans are quite common. One possible mechanism for generating genome-level variation among individuals of this primarily clonal fungus is mutation and mitotic recombination leading to loss of heterozygosity (LOH). Taking advantage of a recently published genome-wide single-nucleotide polymorphism (SNP) map (A. Forche, P. T. Magee, B. B. Magee, and G. May, Eukaryot. Cell 3:705-714, 2004), an SNP microarray was developed for 23 SNP loci residing on chromosomes 5, 6, and 7. It was used to examine 21 strains previously shown to have undergone mitotic recombination at the GAL1 locus on chromosome 1 during infection in mice. In addition, karyotypes and morphological properties of these strains were evaluated. Our results show that during in vivo passaging, LOH events occur at observable frequencies, that such mitotic recombination events occur independently in different loci across the genome, and that changes in karyotypes and alterations of phenotypic characteristics can be observed alone, in combination, or together with LOH.


Two databases derived from BGC-Argo float measurements for marine biogeochemical and bio-optical applications

Date: 2017-11-22

Creator: Emanuele Organelli

Marie Barbieux

HervƩ Claustre

Catherine Schmechtig

Antoine, Poteau

Annick Bricaud

Emmanuel Boss

Nathan Briggs

Giorgio Dall'Olmo

Fabrizio D'Ortenzio

Edouard Leymarie

Antoine Mangin

Grigor Obolensky

Christophe Penkerc'H

Louis Prieur

Collin Roesler

Romain Serra

Julia Uitz

Xiaogang Xing

Access: Open access

Since 2012, an array of 105 Biogeochemical-Argo (BGC-Argo) floats has been deployed across the world's oceans to assist in filling observational gaps that are required for characterizing open-ocean environments. Profiles of biogeochemical (chlorophyll and dissolved organic matter) and optical (single-wavelength particulate optical backscattering, downward irradiance at three wavelengths, and photosynthetically available radiation) variables are collected in the upper 1000 m every 1 to 10 days. The database of 9837 vertical profiles collected up to January 2016 is presented and its spatial and temporal coverage is discussed. Each variable is quality controlled with specifically developed procedures and its time series is quality-assessed to identify issues related to biofouling and/or instrument drift. A second database of 5748 profile-derived products within the first optical depth (i.e., the layer of interest for satellite remote sensing) is also presented and its spatiotemporal distribution discussed. This database, devoted to field and remote ocean color applications, includes diffuse attenuation coefficients for downward irradiance at three narrow wavebands and one broad waveband (photosynthetically available radiation), calibrated chlorophyll and fluorescent dissolved organic matter concentrations, and single-wavelength particulate optical backscattering. To demonstrate the applicability of these databases, data within the first optical depth are compared with previously established bio-optical models and used to validate remotely derived bio-optical products. The quality-controlled databases are publicly available from the SEANOE (SEA scieNtific Open data Edition) publisher at https://doi.org/10.17882/49388 and https://doi.org/10.17882/47142 for vertical profiles and products within the first optical depth, respectively.