Showing 51 - 60 of 5830 Items
The Conspiracy of Balkis: Translating Monique Wittig's Feminist Novel "Les Guérillères" Access to this record is restricted to members of the Bowdoin community. Log in here to view.
Date: 2025-01-01
Creator: Alyssa Nicole Bommer
Access: Access restricted to the Bowdoin Community
Shining a Light on ‘Like Dissolves Like’: Effects of Cocrystals and Excipients on the Dissolution Performance of Mefenamic Acid Access to this record is restricted to members of the Bowdoin community. Log in here to view.
Date: 2025-01-01
Creator: Runqin Chen
Access: Access restricted to the Bowdoin Community
Co-modulation of the Pyloric Circuit in the Stomatogastric Nervous System of the
Cancer Borealis
Date: 2025-01-01
Creator: Margaret Broaddus
Access: Open access
- ABSTRACT CHAPTER I: All nervous systems are influenced by circulating hormones, which can modulate neural circuits to produce different outputs from the same set of neurons. Invertebrate models, particularly crustaceans, serve as excellent models for studying neuromodulation because they contain neural circuits that continue to generate fictive activity when dissected out of the animal. The stomatogastric nervous system (STNS) of the Jonah Crab (Cancer borealis) has long been used to study neuromodulation due to its well-characterized circuits. Even in such a compact neural network, little is known about how these circuits are modulated, and this remains a question in all animals, particularly in humans. Here we investigated the modulation of the pyloric circuit by applying bulk hemolymph to the dissected STNS preparation. The hemolymph contains all of the circulating modulators, some of which have known effects on the pyloric rhythm (though many are still unknown). Interestingly, when hemolymph is applied to the isolated STNS, the pyloric rhythm is suppressed. This is surprising given that in vivo the STNS is continually exposed to hemolymph (the STG is situated within an artery, and thus, exposed to circulating hemolymph) and the pyloric rhythm is constitutively active. Therefore, I hypothesized that there are synaptically released neurotransmitters that excite the pyloric rhythm. To test this hypothesis, we applied three different excitatory modulators – proctolin, serotonin, and oxotremorine – separately in the presence of hemolymph. I found that proctolin and oxotremorine restore the pyloric rhythm in the presence of hemolymph. However, serotonin did not consistently overcome the inhibition of hemolymph. ABSTRACT CHAPTER II: A plethora of work has begun to identify how endogenous neural and hormonal modulators interact to influence the pyloric network. Here we examined the modulation of the stomatogastric nervous system (STNS) via two excitatory endogenous modulators CabTRP Ia and corazonin. CabTRP Ia and corazonin both excite the pyloric rhythm, but in distinct ways. Preliminary data by Nusbaum and Christie from 2003 suggested that an initial corazonin application gated a stronger response to subsequent CabTRP Ia when compared the inverse application of these neuromodulators. We sought to validate this gating phenomenon, but found no significant difference between the effects of the first and second applications of CabTRP Ia. Given that these animals are wild caught and surviving in a changing oceanic environment, it is possible that this modulatory effect in the Jonah Crab has changed over the last few decades due to environmentally driven shifts in receptor expression and channel conductances.
Redefining Warfare: The Role of International Humanitarian Law in Governing Cyber Conflict Access to this record is restricted to members of the Bowdoin community. Log in here to view.
Date: 2025-01-01
Creator: Carina Lim-Huang
Access: Access restricted to the Bowdoin Community
Is Prompt Engineering Effective Enough? Why ChatGPT’s Bias Needs More Than a Quick Band-Aid Fix
Date: 2025-01-01
Creator: Hamda Abdirahman Hussein, Fatima K Kunjo
Access: Open access
Multi-scale effects of environmental stress on Pinus ponderosa Access to this record is restricted to members of the Bowdoin community. Log in here to view.
Date: 2025-01-01
Creator: Cara Sydney Nova Fields
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Shining a light on antimicrobial peptide pore formation: Developing a method to study alamethicin pore dynamics with polarized ATR-FTIR Access to this record is restricted to members of the Bowdoin community. Log in here to view.
Date: 2025-01-01
Creator: Rhys Edwards
Access: Access restricted to the Bowdoin Community
QE1 vs. Abenomics: A Channel-Based Comparison of Japan’s Quantitative Easing Attempts
Date: 2025-01-01
Creator: Sujan Garapati
Access: Open access
- Since 2001, Japan has experienced two extended quantitative easing (QE) periods that aimed to address its low growth and deflationary environment. This paper investigates the transmission channels of the country’s QE policies during both periods: QE1 and Abenomics. Investigating three primary QE channels, signaling, inflation, and safety, the analysis identifies a signaling channel with different characteristics during both periods, no inflation channel, and a safety channel with different strengths during both periods. During QE1, event dates signaled low yields on short- and medium-term bonds but not on long-term bonds, suggesting a weak signaling channel. In contrast, under Abenomics, the signaling channel was strong for long-term bonds, reflecting a credible commitment to sustained low interest rates. Event dates in both periods were associated with deflation, so the evidence does not support the presence of an inflation channel. Across both periods, a significant safety channel was present. Investors paid a premium for safe assets that decreased yields as the BOJ purchased bonds, especially during Abenomics. The findings suggest that Abenomics was more successful at decreasing interest rates than QE1. Overall, this paper reveals that QE can effectively lower yields through signaling and safety effects but fails to raise inflation expectations in Japan.
Developing an Exogenous Expression System
for the Purification and Isolation of srGAP1 Access to this record is restricted to members of the Bowdoin community. Log in here to view.
Date: 2025-01-01
Creator: Philip Spyrou
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Investigating the role of calcium-activated potassium channels in the stabilization of mammalian spinal locomotor activity Access to this record is restricted to members of the Bowdoin community. Log in here to view.
Date: 2025-01-01
Creator: Aeri Ko
Access: Access restricted to the Bowdoin Community