Showing 171 - 180 of 2040 Items
Date: 2019-07-03
Creator: Crystal Hall
Access: Open access
- This article examines the relationship between two fields of study, Italian Studies and Digital Humanities (DH), by documenting projects that employ digital or computational methods in the study of Italian language, literature, history, and the arts. In a complementary fashion, the author outlines the analytical questions of Italian scholars that have potential to advance inquiry in DH. A final section is devoted to contextualizing DH within the practice of Italian Studies at the institutional, program, and department levels by drawing on research of course offerings and a survey circulated in August 2017. The overall finding is that the area of overlap between DH and Italian Studies is intellectually rich, with increasing (yet still sparse) opportunities to develop specialization in this area.
Date: 2022-01-01
Creator: Charles Dorn
Access: Open access
- Alongside Walt Disney’s animated movies, television programming, and theme parks, scholars have examined The Walt Disney Studios’ True-Life Adventures series of live-action nature documentary films for their impact on popular culture. Historians, however, have mostly overlooked the significance of the True-Life Adventures for student learning about the natural world. Amending this historiographical shortcoming, this essay examines Disney’s innovative approach to wildlife filmmaking, describes viewers’ reactions to the True-Life Adventures’ educational qualities, and investigates the Studios’ efforts to use the films to enter the education market. The study breaks new ground by analyzing seldom accessed documents preserved in theWalt Disney Archives both to reveal how students, teachers, and college and university faculty responded to the films and to examine the extension of the nature documentaries through related media.
Date: 2012-01-01
Creator: William K. Richard
Stephen M. Majercik
Access: Open access
Date: 2014-11-04
Creator: Therese Cahill Low
Access: Open access
Date: 2014-06-27
Creator: Shawn Yardley
Access: Open access
Date: 2014-11-04
Creator: Alivia Moore
Access: Open access
Date: 2014-06-25
Creator: Lucille Atwell
Access: Open access
Date: 2014-12-18
Creator: Mikhu Paul
Access: Open access
Date: 2004-10-01
Creator: William R. Jackman
Bruce W. Draper
David W. Stock
Access: Open access
- We have investigated fibroblast growth factor (FGF) signaling during the development of the zebrafish pharyngeal dentition with the goal of uncovering novel roles for FGFs in tooth development as well as phylogenetic and topographic diversity in the tooth developmental pathway. We found that the tooth-related expression of several zebrafish genes is similar to that of their mouse orthologs, including both epithelial and mesenchymal markers. Additionally, significant differences in gene expression between zebrafish and mouse teeth are indicated by the apparent lack of fgf8 and pax9 expression in zebrafish tooth germs. FGF receptor inhibition with SU5402 at 32 h blocked dental epithelial morphogenesis and tooth mineralization. While the pharyngeal epithelium remained intact as judged by normal pitx2 expression, not only was the mesenchymal expression of lhx6 and lhx7 eliminated as expected from mouse studies, but the epithelial expression of dlx2a, dlx2b, fgf3, and fgf4 was as well. This latter result provides novel evidence that the dental epithelium is a target of FGF signaling. However, the failure of SU5402 to block localized expression of pitx2 suggests that the earliest steps of tooth initiation are FGF-independent. Investigations of specific FGF ligands with morpholino antisense oligonucleotides revealed only a mild tooth shape phenotype following fgf4 knockdown, while fgf8 inhibition revealed only a subtle down-regulation of dental dlx2b expression with no apparent effect on tooth morphology. Our results suggest redundant FGF signals target the dental epithelium and together are required for dental morphogenesis. Further work will be required to elucidate the nature of these signals, particularly with respect to their origins and whether they act through the mesenchyme. © 2004 Elsevier Inc. All rights reserved.
Date: 2013-02-07
Creator: Meleah A. Hickman
Guisheng Zeng
Anja Forche
Matthew P. Hirakawa
Darren, Abbey
Benjamin D. Harrison
Yan Ming Wang
Ching Hua Su
Richard J. Bennett
Yue Wang
Judith Berman
Access: Open access
- Candida albicans, the most prevalent human fungal pathogen, is considered to be an obligate diploid that carries recessive lethal mutations throughout the genome. Here we demonstrate that C. albicans has a viable haploid state that can be derived from diploid cells under in vitro and in vivo conditions, and that seems to arise through a concerted chromosome loss mechanism. Haploids undergo morphogenetic changes like those of diploids, including the yeast-hyphal transition, chlamydospore formation and a white-opaque switch that facilitates mating. Haploid opaque cells of opposite mating type mate efficiently to regenerate the diploid form, restoring heterozygosity and fitness. Homozygous diploids arise spontaneously by auto-diploidization, and both haploids and auto-diploids show a similar reduction in fitness, in vitro and in vivo, relative to heterozygous diploids, indicating that homozygous cell types are transient in mixed populations. Finally, we constructed stable haploid strains with multiple auxotrophies that will facilitate molecular and genetic analyses of this important pathogen. © 2013 Macmillan Publishers Limited. All rights reserved.