Showing 111 - 120 of 733 Items
Data Set for North American Colleges and Universities with Italian and Digital Humanities Programs
Date: 2016-09-13
Creator: Crystal Hall
Access: Open access
- This data set represents a first attempt to identify the North American colleges and universities that offer Italian courses at any level and also have support for digital humanities (DH) pedagogy or scholarship at any level. The list of schools with Italian programs was developed using the American Association of Teachers of Italian (AATI) list of undergraduate and graduate programs and College Source as of July 2016. The list was supplemented by checking if institutions listed with CenterNet (for Digital Humanities Centers) also have Italian programs. Overall, 10% of the Italian programs identified were not included in the AATI list, from the level of service courses through Masters degree. A search of each institution’s website was then performed to determine the level of DH resources available. Based on this collected data, 70% of North American colleges and universities that offer Italian also offer support for digital humanities courses or research through a center/lab, courses, major or minor programs, certificates, or graduate programs. A supplemental code sheet is available. Further analysis is provided in the author’s working paper “Digital Humanities & Italian Studies: Intersections and Oppositions” that is part of the State of the Discipline symposium organized by Wellesley College, October 1, 2016. (The data has been updated since the circulation of that paper, so numbers may not match.) The topic will be addressed in more detail based on the related survey and presentation at MLA 2017.
Analysis of the yeast arginine methyltransferase Hmt1p/Rmt1p and its in vivo function. Cofactor binding and substrate interactions
Date: 2000-02-04
Creator: Anne E. McBride, Valerie H. Weiss, Heidi K. Kim, James M. Hogle, Pamela A., Silver
Access: Open access
- Many eukaryotic RNA-binding proteins are modified by methylation of arginine residues. The yeast Saccharomyces cerevisiae contains one major arginine methyltransferase, Hmt1p/Rmt1p, which is not essential for normal cell growth. However, cells missing HMT1 and also bearing mutations in the mRNA-binding proteins Np13p or Cbp80p can no longer survive, providing genetic backgrounds in which to study Hmt1p function. We now demonstrate that the catalytically active form of Hmt1p is required for its activity in vivo. Amino acid changes in the putative Hmt1p S-adenosyl-L-methionine-binding site were generated and shown to be unable to catalyze methylation of Np13p in vitro and in vivo or to restore growth to strains that require HMT1. In addition these mutations affect nucleocytoplasmic transport of Np13p. A cold- sensitive mutant of Hmt1p was generated and showed reduced methylation of Np13p, but not of other substrates, at 14 °C. These results define new aspects of Hmt1 and reveal the importance of its activity in vivo.
Reference Points, Prospect Theory, and Momentum on the PGA Tour
Date: 2016-06-01
Creator: Daniel F. Stone, Jeremy Arkes
Access: Open access
- Pope and Schweitzer (2011) study predictions of prospect theory for the reference point of par on the current hole in professional golf. We study prospect-theory predictions of three other plausible reference points: par for recent holes, for the round, and for the tournament. A potentially competing force is momentum in quality of play, that is, the hot or cold hand. While prospect theory predicts negative serial correlation in better (worse)-than-average performance across holes, the hot (cold) hand implies the opposite. We find evidence that, for each of the reference points we study, when scores are better than par, hot-hand effects are dominated by prospect-theory effects. These effects can occur via two mechanisms: greater conservatism or less effort. We find evidence that the former (latter) dominates for scores closer to (further from) the reference point. We also find evidence of prospect theory effects (greater risk seeking) when scores are worse than par for the round in Round 1 and of cold-hand effects for scores worse than par for the tournament in Round 3. The magnitudes of some of the joint effects are comparable to those found by Pope and Schweitzer and other related papers. We conclude by discussing how, rather than compete, prospect-theory and cold-hand forces might also cause one another.
Holocene peatland carbon dynamics in the circum-Arctic region: An introduction
Date: 2014-01-01
Creator: Zicheng Yu, Julie Loisel, Daniel J. Charman, David W. Beilman, Philip, Camill
Access: Open access
- Peatlands represent the largest and most concentrated carbon pool in the terrestrial biosphere, and their dynamics during the Holocene have had significant impacts on the global carbon cycle. In this Introduction paper, we provide an overview of the contributions presented in this Special Issue on Holocene peatland carbon dynamics. We also provide a brief history and current status of peat-core-based research on peatland carbon dynamics. Finally, we identify and discuss some challenges and opportunities that would guide peatland carbon research in the near future. These challenges and opportunities include the need to fill data gaps and increase geographic representations of peat carbon accumulation records, a better understanding of peatland lateral expansion process and improved estimate of peatland area change over time, developing regional carbon accumulation histories and carbon pool estimates, and projecting and quantifying overall peatland net carbon balance in a changing world.
Aneuploidy and isochromosome formation in drug-resistant Candida albicans
Date: 2006-07-21
Creator: Anna Selmecki, Anja Forche, Judith Berman
Access: Open access
- Resistance to the limited number of available antifungal drugs is a serious problem in the treatment of Candida albicans. We found that aneuploidy in general and a specific segmental aneuploidy, consisting of an isochromosome composed of the two left arms of chromosome 5, were associated with azole resistance. The isochromosome forms around a single centromere flanked by an inverted repeat and was found as an independent chromosome or fused at the telomere to a full-length homolog of chromosome 5. Increases and decreases in drug resistance were strongly associated with gain and loss of this isochromosome, which bears genes expressing the enzyme in the ergosterol pathway targeted by azole drugs, efflux pumps, and a transcription factor that positively regulates a subset of efflux pump genes.
Attention training toward and away from threat in social phobia: Effects on subjective, behavioral, and physiological measures of anxiety
Date: 2012-01-01
Creator: Alexandre Heeren, Hannah E. Reese, Richard J. McNally, Pierre Philippot
Access: Open access
- Social phobics exhibit an attentional bias for threat in probe detection and probe discrimination paradigms. Attention training programs, in which probes always replace nonthreatening cues, reduce attentional bias for threat and self-reported social anxiety. However, researchers have seldom included behavioral measures of anxiety reduction, and have never taken physiological measures of anxiety reduction. In the present study, we trained individuals with generalized social phobia (n = 57) to attend to threat cues (attend to threat), to attend to positive cues (attend to positive), or to alternately attend to both (control condition). We assessed not only self-reported social anxiety, but also behavioral and physiological measures of social anxiety. Participants trained to attend to nonthreatening cues demonstrated significantly greater reductions in self-reported, behavioral, and physiological measures of anxiety than did participants from the attend to threat and control conditions. © 2011 Elsevier Ltd.
Estimated stocks of circumpolar permafrost carbon with quantified uncertainty ranges and identified data gaps
Date: 2014-12-01
Creator: G. Hugelius, J. Strauss, S. Zubrzycki, J. W. Harden, E. A.G., Schuur, C. L. Ping, L. Schirrmeister, G. Grosse, G. J. Michaelson, C. D. Koven, J. A. O'Donnell, B. Elberling, U. Mishra, P. Camill, Z. Yu, J. Palmtag
Access: Open access
- Soils and other unconsolidated deposits in the northern circumpolar permafrost region store large amounts of soil organic carbon (SOC). This SOC is potentially vulnerable to remobilization following soil warming and permafrost thaw, but SOC stock estimates were poorly constrained and quantitative error estimates were lacking. This study presents revised estimates of permafrost SOC stocks, including quantitative uncertainty estimates, in the 0-3 m depth range in soils as well as for sediments deeper than 3 m in deltaic deposits of major rivers and in the Yedoma region of Siberia and Alaska. Revised estimates are based on significantly larger databases compared to previous studies. Despite this there is evidence of significant remaining regional data gaps. Estimates remain particularly poorly constrained for soils in the High Arctic region and physiographic regions with thin sedimentary overburden (mountains, highlands and plateaus) as well as for deposits below 3 m depth in deltas and the Yedoma region. While some components of the revised SOC stocks are similar in magnitude to those previously reported for this region, there are substantial differences in other components, including the fraction of perennially frozen SOC. Upscaled based on regional soil maps, estimated permafrost region SOC stocks are 217 ± 12 and 472 ± 27 Pg for the 0-0.3 and 0-1 m soil depths, respectively (±95% confidence intervals). Storage of SOC in 0-3 m of soils is estimated to 1035 ± 150 Pg. Of this, 34 ± 16 Pg C is stored in poorly developed soils of the High Arctic. Based on generalized calculations, storage of SOC below 3 m of surface soils in deltaic alluvium of major Arctic rivers is estimated as 91 ± 52 Pg. In the Yedoma region, estimated SOC stocks below 3 m depth are 181 ± 54 Pg, of which 74 ± 20 Pg is stored in intact Yedoma (late Pleistocene ice- and organic-rich silty sediments) with the remainder in refrozen thermokarst deposits. Total estimated SOC storage for the permafrost region is ∼1300 Pg with an uncertainty range of ∼1100 to 1500 Pg. Of this, ∼500 Pg is in non-permafrost soils, seasonally thawed in the active layer or in deeper taliks, while ∼800 Pg is perennially frozen. This represents a substantial ∼300 Pg lowering of the estimated perennially frozen SOC stock compared to previous estimates.
Kernel functions on domains with hyperelliptic double
Date: 1977-01-01
Creator: William H. Barker
Access: Open access
- Iii this paper we show that the structure of the Bergman and Szegö kernel functions is especially simple on domains with hyperelliptic double. Each such domain is conformally equivalent to the exterior of a system of slits taken from the real axis, and on such domains the Bergman kernel function and its adjoint are essentially the same, while the Szegö kernel function and its adjoint are elementary and can be written in a closed form involving nothing worse than fourth roots of polynomials. Additionally, a number of applications of these results are obtained. © 1977 American Mathematical Society.
The premonitory urge to tic: Measurement, characteristics, and correlates in older adolescents and adults
Date: 2014-01-01
Creator: Hannah E. Reese, Lawrence Scahill, Alan L. Peterson, Katherine Crowe, Douglas W., Woods, John Piacentini, John T. Walkup, Sabine Wilhelm
Access: Open access
- In addition to motor and/or vocal tics, many individuals with Tourette syndrome (TS) or chronic tic disorder (CTD) report frequent, uncomfortable sensory phenomena that immediately precede the tics. To date, examination of these premonitory sensations or urges has been limited by inconsistent assessment tools. In this paper, we examine the psychometric properties of a nine-item self-report measure, the Premonitory Urge to Tic Scale (PUTS) and examine the characteristics and correlates of the premonitory urge to tic in a clinical sample of 122 older adolescents and adults with TS or CTD. The PUTS demonstrated adequate internal consistency, temporal stability, and concurrent validity. Premonitory urges were endorsed by the majority of individuals. Most individuals reported some relief from the urges after completing a tic and being able to stop their tics even if only temporarily. Degree of premonitory urges was not significantly correlated with age, and we did not observe any gender differences. Degree of premonitory urges was significantly correlated with estimated IQ and tic severity, but not severity of comorbid obsessive-compulsive disorder or attention-deficit hyperactivity disorder. Also, it was not related to concomitant medication status. These findings represent another step forward in our understanding of the premonitory sensations associated with TS and CTD. © 2013.
The capacity to act in trans varies among drosophila enhancers
Date: 2016-05-01
Creator: Amanda J. Blick, Ilana Mayer-Hirshfeld, Beatriz R. Malibiran, Matthew A. Cooper, Pieter A., Martino, Justine E. Johnson, Jack R. Bateman
Access: Open access
- The interphase nucleus is organized such that genomic segments interact in cis, on the same chromosome, and in trans, between different chromosomes. In Drosophila and other Dipterans, extensive interactions are observed between homologous chromosomes, which can permit enhancers and promoters to communicate in trans. Enhancer action in trans has been observed for a handful of genes in Drosophila, but it is as yet unclear whether this is a general property of all enhancers or specific to a few. Here, we test a collection of well-characterized enhancers for the capacity to act in trans. Specifically, we tested 18 enhancers that are active in either the eye or wing disc of third instar Drosophila larvae and, using two different assays, found evidence that each enhancer can act in trans. However, the degree to which trans-action was supported varied greatly between enhancers. Quantitative analysis of enhancer activity supports a model wherein an enhancer’s strength of transcriptional activation is a major determinant of its ability to act in trans, but that additional factors may also contribute to an enhancer’s trans-activity. In sum, our data suggest that a capacity to activate a promoter on a paired chromosome is common among Drosophila enhancers.