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Miniature of Role of the Dopamine Subtype 1 Receptor (D<sub>1</sub>R) Modulation of the I<sub>h</sub> Current in Rhythmic Spinal Mammalian Motor Networks
Role of the Dopamine Subtype 1 Receptor (D1R) Modulation of the Ih Current in Rhythmic Spinal Mammalian Motor Networks
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  • Restriction End Date: 2025-06-01

    Date: 2022-01-01

    Creator: Grace Soeun Lee

    Access: Access restricted to the Bowdoin Community

      Miniature of The Current Hunt for Nitric Oxide's Effects on the <i>Homarus americanus</i> Cardiac Ganglion
      The Current Hunt for Nitric Oxide's Effects on the Homarus americanus Cardiac Ganglion

      Date: 2022-01-01

      Creator: Joanna Lin

      Access: Open access

      The crustacean heartbeat is produced and modulated by the cardiac ganglion (CG), a central pattern generator. In the American lobster, Homarus americanus, the CG consists of 4 small premotor cells (SCs) that electrically and chemically synapse onto 5 large motor cells (LCs). Rhythmic driver potentials in the SCs generate bursting in the LCs, which elicit downstream cardiac muscle contractions that are essential for physiological functions. Endogenous neuromodulators mediate changes in the CG to meet homeostatic demands caused by environmental stressors. Nitric oxide (NO), a gaseous neuromodulator, inhibits the lobster CG. Heart contractions release NO, which directly decreases the CG burst frequency and indirectly decreases the heartbeat amplitude, to mediate negative feedback. I investigated NO’s inhibitory effects on the CG to further understand the mechanisms underlying intrinsic feedback. Using extracellular recordings, I examined NO modulation of the SCs and LCs when coupled in the intact circuit and when firing independently in the ligatured preparation. Using two-electrode voltage clamp, I additionally analyzed the modulation of channel kinetics. Based on previous studies, I hypothesized that NO decreases the burst frequency of the LCs and SCs by modulating conductance properties of the voltage-gated A-type potassium current (IA). My data showed that NO decreased the burst frequency in the LCs and the burst duration in the SCs in a state-dependent manner. Furthermore, NO increased the IA inactivation time constant to decrease the LCs’ burst frequency. Thus, NO mediated inhibitory effects on cardiac output by differentially targeting both cell types and altering the IA current kinetics.
      Miniature of Modulation of ionic currents by nitric oxide negative feedback in the lobster cardiac ganglion
      Modulation of ionic currents by nitric oxide negative feedback in the lobster cardiac ganglion
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      • Restriction End Date: 2026-06-01

        Date: 2021-01-01

        Creator: Emily Renee King

        Access: Access restricted to the Bowdoin Community

          Miniature of Attentional Inhibition of a Distractor on Memory Facilitation
          Attentional Inhibition of a Distractor on Memory Facilitation
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              Date: 2016-05-01

              Creator: Jacob M MacDonald

              Access: Access restricted to the Bowdoin Community

                Miniature of Efficacy of Curcumin as a Neuroprotectant Against Dibutyl Phthalate (DBP) - Induced Effects on the Mammalian Spinal Cord Locomotor Neural Network
                Efficacy of Curcumin as a Neuroprotectant Against Dibutyl Phthalate (DBP) - Induced Effects on the Mammalian Spinal Cord Locomotor Neural Network
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                  • Embargo End Date: 2027-05-15

                  Date: 2024-01-01

                  Creator: Eliza Schotten

                  Access: Embargoed

                    Miniature of The modulation of calcium-activated potassium channels for the stabilization of mammalian spinal locomotor activity
                    The modulation of calcium-activated potassium channels for the stabilization of mammalian spinal locomotor activity
                    This record is embargoed.
                      • Embargo End Date: 2026-12-14

                      Date: 2023-01-01

                      Creator: Hattie Sargent Slayton

                      Access: Embargoed

                        Neuroscience and Neurobiology Molecular and Cellular Neuroscience Homarus americanus Systems Neuroscience Behavioral Neurobiology cardiac ganglion central pattern generator EEG Cellular and Molecular Physiology Other Neuroscience and Neurobiology neuromodulation Cognitive Neuroscience Developmental Neuroscience Life Sciences Memory early life adversity episodic memory lobster CPG Cognitive control central pattern generators electrophysiology maternal separation modulation parvalbumin temperature Aneuploidy Bioinformatics Candida albicans Computational Neuroscience ERP Gryllus bimaculatus Locomotion anxiety cricket crustacean development myosuppressin neuromuscular junction plasticizer prefrontal cortex sex differences Adolescent Animal Experimentation and Research Attention Brain Cancer borealis Central pattern generators Cognition and Perception Compensatory plasticity EJP Episodic memory Female Humans IOR Information theory Item memory LOH Laboratory and Basic Science Research Loss of heterozygosity Magnetic Resonance Imaging Male Mental Recall Nervous System Diseases Neurosciences Neurotrophins Parvalbumin Source memory Systems and Integrative Physiology Theta Toll receptors Tributyl phosphate (TBP) Young Adult behavior cardiac cardiac muscle cardiac neuromuscular system cold-deactivation crab feedback fictive locomotion ion channels ketamine locomotion motor neuron neuromodulator neuropeptides nitric oxide oscillations plasticity receptors salinity stomatogastric nervous system stretch stretch feedback theta oscillations 5-methylcytosine 5HTTLPR 81-B-5 A-type potassium current AVGSEFLamide Active Adaptation Adult Alpha oscillations American lobster American lobster (Homarus americanus) Amidation Analysis of Variance Anxiety Association Learning Auditory System BDNF Basal ganglia Behavior Beta Rhythm Beta oscillations Biological Clocks Biological Psychology Biology Brain Mapping C-Type Allatostatin C-type allatostatin CNS CPGs Candida Candida krusei Carassius auratus Central Pattern Generator Central Pattern Generators (CPGs) Central pattern generator Chemicals and Drugs Choice Cognitive Psychology Colony phenotype Comparative and Evolutionary Physiology Computational Biology Context specificity Control network Control operations Crustacean Cryptococcus D1R agonist DAT DNA methylation DRG Deafferentation Decision Decision making DeepLabCut Dendritic sprouting Discriminability Distributed networks Dopamine Drift diffusion model Early Life Adversity Electroencephalography Electroencephalography (EEG) Emotions Encoding Environmental Health Environmental Public Health Episodic Memory Episodic retrieval Event-related potentials (ERPs) Evoked Potentials Executive functions Experimental Analysis of Behavior Fitness Fluconazole resistance Font fan Frontal lobes Fungal pathogens GSEFLamide GYS Gamma Genome Report Genome plasticity Genome rearrangement Granger Causality HCN Channel HCN1 channel Heterozygosity Homeostatic plasticity Hyper-variability Hyperpolarization Activated Inward Current Image Processing, Computer-Assisted Imagination Inter-homolog recombination Issue 159 Judgment L-Glutamatic acid Laboratory course Levels of processing Long-Term Memory Lumbar Nerves Majoid Mammalian Spinal Cord Mating type locus Meditation Memory retrieval Memory, Episodic Mice Midazolam Mindfulness Mindfulness meditation Molecular Genetics Motor Control Multimodal Imaging NMJ Navigation Neural Pathways Neural network model Neural plasticity Neuromodulation Neuropeptide Neuropeptides Neuropsychological assessment Neuroscience education Novelty Nyhus Oropharyngeal candidiasis Oscillations Oscillatory signals Other Animal Sciences Oxygen PIR Pattern generator Perceptual match Pharmacology Pharmacy and Pharmaceutical Sciences Photic Stimulation Physical Sciences and Mathematics Physiological Response Physiology Prefrontal cortex Public Health RNA RNA-Seq RT-qPCR Rad51 Rad52 Rad59 Reaction Time Recognition memory Reinforcement learning Response uncertainty Rhythmogenesis Rosmarinic acid (RA) SGRN SLC6A4 SLY neuropeptide family SNP-RFLP STNS Set shifting Sex Differences Sexual dimorphism Single-strand annealing Social approach Spaeztle Spinal Cord Spz Spz Proteins Stomatogastric nervous system Subthalamic nucleus TRPV4 TRPV4 antagonist Task-switching Theta oscillations Thoracic Spinal Network Toll Toll 6-1 Toll Proteins Toll proteins Top-down control Toxicology Transient network Transporters Trunk Motor Behaviors Ultrasonic vocalizations V1a-like receptor Vasotocin Ventrolateral prefrontal cortex Virtual reality Visual Perception Wisconsin Card Sorting Test Working memory ZD7288 active force adenylyl cyclase affective processing afterload pressure alpha power alpha rhythm amine amygdala androgen anxiety-like behavior article ascending neuron attention auditory processing basolateral amygdala behavioral neuroscience bioinformatics bursting stability c-Fos calcium-activated potassium channels cellular neurophysiology central pattern generation central pattern generator (CPG) central pattern generator (CPG) network chill coma circuit compensatory plasticity corticolimbic development corticosterone crash crash temperature cricket embryos curcumin deafferentation decision making dendritic plasticity depression dibutyl phthalate differential gene expression dopamine early-life adversity electrical stimulation electroencephalogram elevated zero maze entrainment estrogen estrogen receptor ethological behaviors evoked response evolution excitatory junction potential executive function flexibility forskolin frontoparietal network functional magnetic resonance imaging gastric mill groupSIFT gryllus bimaculatus heartbeat heartbeat frequency human hyperdopaminergic transmission hyperpolarization-activated inward current in situ hybridization inhibition interneurons intrinsic properties irregularity isolated cardiac ganglion item memory limb bud lobster cardiac ganglion lumbar CPG machine learning majoid mammalian spinal cord medial temporal lobe membrane receptors memory retrieval mindfulness meditation modulatory capacity motor neurons motor output mouse muscle contraction mushroom bodies negative feedback neonatal mouse spinal cord nerve cell nerve cell oscillation neural circuits neuronal excitation neuronal nitric oxide synthase (nNOS) neuropeptide neuroplasticity neuroprotectant neuroprotection neuroscience nitric oxide feedback non-genomic noninvasive neuromodulation normal human octopamine old/new effect oxidative stress patch clamp pattern generator peltier element peptide signaling peripheral nervous system development phasic pheromone plastic pollution post translational modifications post-retrieval monitoring posterior parietal cortex priority journal prothoracic ganglia pyloric filter rPDC reciprocal inhibition recognition renormalized Partial Directed Coherence reproduction restless legs syndrome rhythmic motor output semaphorin sensory feedback sex-specific site(s) of modulation social behavior social preference source retrieval spinal cord stereotaxic stimulation stereotaxic surgery steroid structural plasticity tACS task performance thermal robustness thermosensation theta rhythm transcriptome translational models tyramine ultrasonic vocalization playback unsupervised clustering ventral root ventral roots visual memory visual stimulation y-Aminobutyric acid zebrafish