Showing 1021 - 1030 of 2039 Items
MAO-A phenotype effects response sensitivity and the parietal old/new effect during recognition memory
Date: 2018-02-13
Creator: Robert S. Ross
Andrew Smolen
Tim Curran
Erika Nyhus
Access: Open access
- A critical problem for developing personalized treatment plans for cognitive disruptions is the lack of understanding how individual differences influence cognition. Recognition memory is one cognitive ability that varies from person to person and that variation may be related to different genetic phenotypes. One gene that may impact recognition memory is the monoamine oxidase A gene (MAO-A), which influences the transcription rate of MAO-A. Examination of how MAO-A phenotypes impact behavioral and event-related potentials (ERPs) correlates of recognition memory may help explain individual differences in recognition memory performance. Therefore, the current study uses electroencephalography (EEG) in combination with genetic phenotyping of the MAO-A gene to determine how well-characterized ERP components of recognition memory, the early frontal old/new effect, left parietal old/new effect, late frontal old/new effect, and the late posterior negativity (LPN) are impacted by MAO-A phenotype during item and source memory. Our results show that individuals with the MAO-A phenotype leading to increased transcription have lower response sensitivity during both item and source memory. Additionally, during item memory the left parietal old/new effect is not present due to increased ERP amplitude for correct rejections. The results suggest that MAO-A phenotype changes EEG correlates of recognition memory and influences how well individuals differentiate between old and new items.
Statement by Lisa Bullard collected by Rachel George on July 10, 2014
Date: 2014-07-10
Creator: Lisa Bullard
Access: Open access
Statement by Brian Chapla collected by Rachel George on October 14, 2014
Date: 2014-10-14
Creator: Brian Chapla
Access: Open access
Statement by Peter Walsh collected by Charlotte Bacon on April 23, 2015
Date: 2015-04-23
Creator: Peter Walsh
Access: Open access
Statement by Martha Proulx collected by Rachel George on September 17, 2014
Date: 2014-09-17
Creator: Martha Proulx
Access: Open access
Interview with Bob Rozen (2) by Diane Dewhirst
Date: 2009-11-20
Creator: Robert 'Bob' M Rozen
Access: Open access
- Biographical NoteRobert Martin “Bob” Rozen was born on December 11, 1955, in Richmond, Kentucky, to Morris and Rosalyn (Eilenberg) Rozen. He majored in Soviet studies at Miami University (Ohio), graduating in 1977; he earned his law degree at George Washington University. He interned for Senator Wendell Ford as a legislative assistant for the Senate Finance Committee and then continued to work for him after law school. He also earned a master’s in tax law from Georgetown University. He worked on Senator Mitchell’s staff addressing tax, trade, and financial service issues. SummaryInterview includes discussion: capital gains; Mitchell’s work to block the decrease in the capital gains tax in 1989; Mitchell’s work to pass Clinton’s health care reform plan in 1994; Mitchell’s and Moynihan’s relationship; shuttle diplomacy on health care legislation; reconciliation, and Senator Byrd’s role; Mitchell’s leadership style; Mitchell’s work with Paul Sarbanes; Mitchell and Don Riegle; Mitchell and Maine’s interests; relationship between Senators Mitchell and Cohen and their staffs; and appointment of a woman as secretary of state in 1996.
Interview with Sherman Saperstein by Andrea L’Hommedieu
Date: 2010-04-28
Creator: Sherman H Saperstein
Access: Open access
- Biographical NoteSherman Saperstein was born in Waterville, Maine, on March 16, 1932, to Rose (Rosenthal) and Edward Saperstein, entered the family business in 1954, and remained there until the business was sold in 1997. A childhood friend of the Mitchell family, he was also a fund raiser for George Mitchell’s campaigns. At the time of this interview, he was a resident of Scottsdale, Arizona. SummaryInterview includes discussion of: early family life in Waterville, Maine; being a classmate and childhood friend of George Mitchell et al.; Mitchell’s traits and personality; his selection to Boys State and election there as senator; characterization of the Mitchell family.
Interview with Harris Wofford by Brien Williams
Date: 2009-06-12
Creator: Harris L Wofford
Access: Open access
- Biographical NoteHarris Llewellyn Wofford was born April 9, 1926, in New York City. He attended the University of Chicago and both Yale and Howard University Law Schools. During World War II he served in the Air Force. From 1954 to 1958 he served as an attorney for the Commission on Civil Rights, then in 1959 began teaching law at Notre Dame. He was an unofficial advisor to Martin Luther King, Jr. and an advisor to John F. Kennedy’s 1960 presidential campaign. He became Kennedy’s special assistant on civil rights and helped form the Peace Corps, serving as the Peace Corps’ special representative to Africa and director of operations for Ethiopia; from 1962 to 1966 he was the associate director of the Peace Corps. In 1966 he became president of the State University of New York at Old Westbury; then, from 1970 to 1978 he was president of Bryn Mawr College. For a year he was Pennsylvania state chairman of the Democratic Party, and in 1987 he was appointed to be Pennsylvania’s secretary of labor and industry. When Pennsylvania Senator John Heinz died in 1991, Governor Casey appointed Wofford to the vacant Senate seat, and Wofford proceeded to win the special election for the seat the following November. He lost reelection in 1994 to Rick Santorum. Since leaving public office, Wofford has served as CEO of the Corporation for National and Community Service, which runs AmeriCorps; been on the boards of America’s Promise, Youth Service America, and the Points of Light Foundation; served on the boards of the Center for Citizen Leadership and Malaria No More; and taught at the University of Maryland at College Park. In 2002 he received the John W. Gardner Leadership Award. At the time of this interview, he was a senior fellow at the Case Foundation and a spokesperson for Experience Wave. SummaryInterview includes discussion of: how Wofford came to be appointed to the Senate; the Pennsylvania special election of 1991; how Senator Mitchell helped fund Wofford’s campaign through the Democratic Senatorial Campaign Committee (DSCC); first impressions of Mitchell; the Senate prayer breakfast; the story of how Mitchell listened to an opera before going to Ireland to work on the peace agreement; supporting Senator Daschle’s bid to become leader; Senator Moynihan’s role in health care reform; the failure of the Clinton health care reform legislation; Wofford’s and James Carville’s strategy to make health care central to the 1991 campaign; the “Kurks and Turds” story; health care as a more fundamental right than the right to a lawyer; Wofford’s relationship with Carville; factors leading to Wofford’s defeat when he sought reelection; the assault weapon ban; Mitchell’s relationship with Senator Dole; how the Clinton health care plan was formulated; Daschle’s alternative health care plan; the first National Service Act and the Hatch-Kennedy Serve America Bill; Wofford’s reaction to Mitchell’s retirement from the Senate; Mitchell’s career after leaving the Senate; Newt Gingrich’s leadership of the House; the need for the Senate to look at a longer-term strategy; the missed opportunities at the end of the Cold War; Mitchell’s dedication to the search for common ground and to serving the common good; and Mitchell as a statesman.
Interview with David Nexon by Brien Williams
Date: 2009-09-18
Creator: David H Nexon
Access: Open access
- Biographical NoteDavid H. Nexon was born in Chicago, Illinois, on April 10, 1945. He received his bachelor’s degree from Harvard University and a Ph.D. in political science from the University of Chicago. From 1988 to 1983, he was senior budget examiner in the Health Branch of the Office of Management and Budget, where he was responsible for the Health Care Financing Administration. From 1983 to 2005, he served as the Democratic health policy staff director for the Senate’s Health, Education, Labor and Pensions Committee and as the senior health policy advisor to Senator Edward M. Kennedy. At the time of this interview, he held the position of senior executive vice president of the Advanced Medical Technology Association ("AdvaMed"), where he is responsible for domestic policy. SummaryInterview includes discussion of: interest in political science, and health focus within that field; work at the Office of Economic Opportunity; status of health care and reform under Carter and Reagan; transition to Reagan and the effects on health care work in Washington; working for Senator Kennedy; why Nexon left Kennedy’s staff in 2005; Kennedy’s interest in health care; Kennedy’s leadership style; health care under George H.W. Bush; Bill Clinton’s commitment to health care; Nexon’s responsibilities; how Clinton’s health care plan was modified; Mitchell’s role in Clinton’s health care bill; Nexon’s interactions with Senators Moynihan and Chafee; politics of universal health care; the Kennedy-Mitchell relationship; Mitchell’s role in health care; and Nexon’s interactions with the press.
Interview with Jeff and Mary Porter by Andrea L’Hommedieu
Date: 2009-06-25
Creator: Jeffrey 'Jeff' W Porter
Mary A Porter
Access: Open access
- Biographical NoteMary Adele (Federle) Porter was born in Bronxville, New York, on July 23, 1966. Mary’s father, Victor Federle, was trained as a lawyer but worked in the shoe industry in Maine for Scoa Industries; her mother, Antoinette Federle, was a homemaker. Mary was the eighth of nine children and grew up in Waterville, Maine, where she was family friends with the Mitchells. Mary attended Colby College and took an internship in Senator Mitchell’s Washington, D.C. office during her junior year. Jeffrey Wade “Jeff” Porter was born in January, 1966, in Portland, Maine. His parents, Yvonne (Cupo) Porter and John Warren Porter, were both teachers. Jeff attended the University of Maine, Orono and then transferred to the University of Southern Maine, where he also received an internship in Senator Mitchell’s office. After graduating, Jeff continued to work for the senator in the Portland, Maine, field office. SummaryInterview includes discussion of: Mary’s familiarity with Mitchell and his family in Waterville; how Mary and Jeff got internships with Senator Mitchell; Mary and Jeff’s respective political backgrounds growing up; Mitchell’s focus on hiring students from Maine to intern in his office; responsibilities of interns in Mitchell’s office; description of Mary McAleney and Gayle Cory; relationship between Mitchell’s DC and Maine offices; Mitchell as Senate majority leader; Mitchell’s 1988 reelection campaign; Jeff getting to know Mitchell personally by driving him on campaign routes; Mitchell’s relationship with Senator Dole; Senator Muskie’s influence on Mitchell; and the Mitchell Institute and scholarships.