Honors Projects
Showing 481 - 490 of 564 Items
Superhero Ecologies: An Environmental Reading of Contemporary Superhero Cinema
Date: 2019-05-01
Creator: Andrew McGowan
Access: Open access
Identifying a distinct developmental module in the zebrafish dentition
Date: 2018-01-01
Creator: Caleb Matthew Gordon
Access: Open access
- In the zebrafish pharynx, the first three teeth to form, 3V1, 4V1, and 5V1, have distinct adult and embryonic morphologies, suggesting that these teeth may form using different developmental pathways. Previous studies of gene expression profiles and mutant phenotypes in 3V1, 4V1, and 5V1 have identified four genes that might be involved in dissociating these tooth modules: pitx2b, eve1, pbx1a, and pbx1b. To determine how the developmental roles of these four genes differ across 3V1, 4V1, and 5V1, and obtain a better understanding of how these three teeth develop, I performed CRISPR/Cas9– mediated knockouts in each of these genes, or analyzed embryos from a stable transgenic mutant line where available, and observed the resulting tooth germs and mineralized tooth structures via fluorescence and confocal microscopy. Preliminary results implicate pitx2 as being required for tooth mineralization, offer a possible role for pbx1a, pbx1b, and eve1 in distinguishing the developmental pathway of 3V1, and suggest that 3V1 constitutes a distinct developmental module within the early ventral dentition.
“I’m Going to Help You Become a Better You”: Teacher-Student Dynamics in Special Education
Date: 2019-05-01
Creator: Sophie Sadovnikoff
Access: Open access
- This study explores teachers’ roles in special education in terms of how they interact with students with disabilities. In the struggle against oppression and disempowerment, teachers can play a crucial role in employing education as the great equalizer, or else not. The question this research seeks to answer is: how do special education teachers interact with their students with disabilities, and how does this teacher role fit within a society that seeks to marginalize these students? I argue that special education teachers reproduce ableism by disciplining, normalizing, and controlling their students, but teachers express a deep sense of caring for and about their students, and understand their work as being their best effort at helping their students. The ableist actions that they perform are, ironically, an effort to help their students create fulfilling lives within an ableist society.
Ecotourism Reconsidered: Chinese and Western Participation in the Thai Elephant Industry
Date: 2019-05-01
Creator: Miao (Jasmine) Long
Access: Open access
A "Peculiarly American" Enthusiasm: George Bellows, Traditional Masculinity, and The Big Dory
Date: 2014-01-01
Creator: James W. Denison, IV
Access: Open access
- A “Peculiarly American” Enthusiasm: George Bellows, Traditional Masculinity, and The Big Dory investigates the portrayal of masculinity in the oeuvre of the much-lauded yet enigmatic American painter George Bellows (1882-1925). Rather than relying on Bellows’ urban works for source material, a significant portion of this investigation is conducted via a case study of Bellows’ 1913 panel The Big Dory, a scene of fishermen pushing a boat into the North Atlantic off Monhegan Island, Maine that the artist painted during a sojourn on the island in the months after his involvement in the landmark Armory Show in New York. The paper situates The Big Dory within the greater context of the history of the depiction of Maine through the lens of the heroic fisherman. Bellows achieved a heroic effect by forcing the viewer to focus on the labor of the fishermen via their positioning in the near middleground and by echoing the hues and forms of the men elsewhere in the painting, giving the work a sense of visual unity. I argue that these strategies highlight Bellows’ interest in tradition rather than modernism. Armed with this knowledge, Bellows’ other works come more sharply into focus. I reveal that the traditional heterosexual mode of white male identity Bellows represented in The Big Dory was not simply echoed in Bellows’ personal comportment, but in fact pervaded his oeuvre; such masculinity was a reaction by patriarchal American society against the perceived growth of other influences in the early twentieth century. The portrayal of such masculinity is then established as the key underlying feature of the sense of “Americanism” which has traditionally dominated reception of Bellows’ art.
Receptors and Neuropeptides in the Cardiac Ganglion of the American Lobster, Homarus americanus: A Bioinformatics and Mass Spectrometric Investigation
Date: 2019-01-01
Creator: Louis Mendez
Access: Open access
- Central pattern generators (CPGs) are neural networks that generate rhythmic motor patterns to allow organisms to perform stereotypical tasks, such as breathing, scratching, flying, and walking. The American lobster, Homarus americanus, is a simple model system whose CPGs are functionally analogous to those in vertebrate models and model complex rhythmic behaviors. CPGs in many Crustacea, including the American lobster, have been studied because of their ability to maintain biological function after isolation in physiologically relevant conditions. The cardiac ganglion (CG) is a CPG consisting of five larger motor neurons and four smaller pacemaker neurons that innervate the cardiac neuromuscular system and generate electrical bursts that drive patterned behaviors. Neuromodulators, such as neuropeptides, are known to modulate neural output in the CPGs of the American lobster. Currently, neuromodulators affecting the cardiac ganglia are thought to be mainly expressed and secreted outside of the cardiac ganglia, acting as extrinsic neuromodulators. However, there is current evidence to support the idea that neuromodulators can be intrinsically expressed within the cardiac ganglion of the American lobster. Preliminary studies using transcriptomic techniques on genomic and transcriptomic information indicate that neuropeptides are likely expressed within the cardiac ganglion. However, little research has been done to determine whether these neuropeptides are expressed in the cardiac ganglion of the American lobster. Therefore, the purpose of this study is to combine bioinformatics and mass spectrometric techniques to determine whether select neuropeptides are present in the cardiac ganglion within the cardiac neuromuscular system of the American lobster, Homarus americanus. Our data mining techniques using protein query sequences obtained from previously annotated brain and eyestalk transcriptomes resulted in the identification of 22 putative neuropeptides preprohormones from 17 neuropeptide families and 20 putative neuropeptide receptors from 17 neuropeptide receptor families in the CG transcriptome. Additionally, 9 putative neuropeptide receptors from 7 neuropeptide receptor families were detected in the cardiac muscle transcriptome. Of the 17 neuropeptide families detected, receptors for 9 of these neuropeptide families were detected in the CG transcriptome. Receptors for 6 of the neuropeptide families were also present in the cardiac muscle transcriptome. Interestingly, receptors for 6 of neuropeptide families detected were not found in either the CG or cardiac muscle transcriptomes, and receptors for 4 neuropeptide families that weren’t detected in the CG transcriptome were found in the cardiac muscle transcriptome. Therefore, our research suggests that neuropeptides are able to modulate CPG activity extrinsically, either though hormonal or local delivery, or intrinsically. Additionally, neuropeptides were extracted from the stomatogastric ganglion and the commissural ganglion using a scaled-down neuropeptide extraction protocol to estimate the number of tissues required to obtain sufficiently strong mass spectrometry signals. Pooled samples with two commissural ganglia and single samples of a commissural ganglion and a stomatogastric ganglion displayed little signal and an increase in larger peptides and impurities relative to single-tissue samples. Therefore, further optimization of the scaled-down neuropeptide extraction protocol must be done prior to analysis of a cardiac ganglion in the American lobster.
"This is N.Y.C. Not Little Rock": The Battle to Integrate New York City's Public Schools
Date: 2019-01-01
Creator: Anne Fraser Gregory
Access: Open access
- The landmark Brown vs. Board of Education decision of 1954, and its subsequent implementation, offer an essential question: Are segregated schools inherently evil, and is integration the only solution to unequal education? The statistics that illustrate the effects of segregated schooling are indeed staggering. According to a 2016 Government Accountability Office study, the number of schools segregated along racial and economic lines doubled between 2000 and 2013. In New York City, the achievement gap between Black and white students has continued to grow. In 2018, the National Assessment of Achievement Progress reported that 48 percent of white fourth-graders were proficient in math, while only 16 percent of black students met the standard. With a gap of 32 percentage points—growing 5 points since 2015—Black children in New York are consistently behind their white peers in academics. Sixty years ago, New York's Black and Latino parents parents grappled with this same issue as they fought to desegregate the city’s schools. This Honors Project will discuss segregated schooling in New York City during the 1950s and 60s, and the actors who fought to disrupt the system. Throughout this work, I will attempt to illustrate the power of community in New York City, for both good and evil, for equality and bigotry. Parents—Black, white, and Puerto Rican—function as key players in this story, as they continually fought local and state Boards to access the education they believed to be rightfully theirs and their children’s. I will also assert the notion that segregation was not solely a Southern issue: the similarities between the fight for school integration in both North and South are striking, and highlight the far reaches of prejudice in the nation both then and now. Most importantly, I argue that unequal education may not be solved by integration alone, and that believing in integration as the only viable option perpetuates the incorrect notion that children of color require proximity to white students in order to be academically successful.
The Future Regained: Toward a Modernist Ethics of Time
Date: 2020-01-01
Creator: Jack Rodgers
Access: Open access
- This project explores the convergence of futurity and ethics through an examination of key figures in modernist literature. It studies works by Virginia Woolf, Marcel Proust, and James Joyce in order to conceptualize an encounter with the future which goes beyond a traditionally linear and teleological model of time, setting out to reimagine the role of both temporality and ethics in novels including Orlando, Mrs. Dalloway, In Search of Lost Time, and Ulysses. Key facets of this exploration, which is metaphorized and guided by the image of a window, include temporal otherness, transgression and fracturing of the self (primarily understood through the paradoxical experience of dying), and the arrival of the future into the present. Major theoretical influences include queer theory, poststructuralism, and anti-dialectics. Ultimately, the project makes the case that it is possible to construct a modernist ethics which embraces the messianic potential of absences, blanks, and blind spots, a proposition made possible by our encounter with an incomprehensible yet imminent fragment of the future out of place in the present. At the close, it suggests an ethical imperative towards “affirmative negation”—a messianic, annunciatory, affirmation of that which is missing or omitted.
Differential gene expression during compensatory plasticity in the prothoracic ganglion of the cricket, Gryllus bimaculatus Access to this record is restricted to members of the Bowdoin community. Log in here to view.
Date: 2020-01-01
Creator: Felicia F. Wang
Access: Access restricted to the Bowdoin Community
Interaction of stretch feedback and beat regularity in response to AMGSEFLamide in the heart of Homarus americanus
Date: 2020-01-01
Creator: William Allen
Access: Open access
- Central pattern generators (CPGs) are neural circuits whose component neurons possess intrinsic properties and synaptic connections that allow them to generate rhythmic motor outputs in the absence of descending inputs. The cardiac ganglion (CG) is a nine-cell CPG located in the American lobster, Homarus americanus. Stretch of the myocardium feeds back to the CG through mechano-sensitive dendrites and is thought to play a role in maintaining regularity in the beating pattern of the heart. The novel peptide AMGSEFLamide has been observed to induce irregular beating patterns when applied at high concentrations. This study investigated the interaction between stretch-related feedback and AMGSEFLamide modulation in generating irregular beating patterns in the whole heart of Homarus americanus. It was hypothesized that greater longitudinal stretch of the heart would result in greater regularity in the instantaneous beat frequency, based on previous findings that stretch-sensitive dendrites play a role in the regulation of the heartbeat. Furthermore, it was predicted that the elimination of stretch feedback via deafferentation of the heart would augment the irregularity induced by AMGSEFLamide. Data showed significantly increased irregularity in beating in response to 10-6 M AMGSEFLamide application. Longitudinal stretch did not reliably alter baseline variability in frequency, nor did it influence the modulatory effect of AMGSEFLamide. Deafferentation did not significantly alter baseline irregularity. Deafferented preparations did exhibit a trend of responding to AMGSEFLamide with a greater percent increase in irregularity compared to when afferents were intact, suggesting a potential role of stretch-stabilization in response to modulatory perturbations in the Homarus heart.