Honors Projects
Showing 231 - 240 of 298 Items
Eroding the Bedrock: The Future of Public Administration Without Chevron Deference
Date: 2024-01-01
Creator: Rose Keller
Access: Open access
- When Congress passes a bill, it produces words on a page. Who decides what those words mean? Historically, the onus of a statute’s interpretation has rested with the federal agencies charged with its implementation. The Chevron doctrine, a two-step standard that affords federal agencies significant latitude in interpreting their own enabling legislation, has been the applicable deference regime in statutory interpretation cases since 1984. Contrary to this tradition, recent Supreme Court jurisprudence has reasserted the primacy of the judiciary in statutory interpretation cases, often ignoring Chevron entirely. In 2023, the Court granted certiorari to Loper Bright Enterprises v. Raimondo, a case that explicitly asked the Court to consider overruling Chevron vs. NRDC, a foundational case in the field of administrative law. This thesis explores the implications of eroding deference to federal agencies through a case study of the Food and Drug Administration and two of its responsibilities. Ultimately, there are potentially negative consequences to limiting agency jurisdiction via eviscerating judicial deference that counsel a more discerning approach.
An AGN as a Counterpart for Neutrino Event IceCube-220303A
Date: 2024-01-01
Creator: Nur Schettino
Access: Open access
- Cosmic rays have been detected for over a century. While some sources have been confirmed, they cannot explain the high energy of the particles (> 10^15 eV), so it remains unclear where and how they are accelerated to extreme energies. The study of astrophysical high-energy neutrinos may help solve the puzzle. These neutrinos are produced by cosmic rays interacting with other charged particles or photons. Moreover, while cosmic rays do not reveal their sources of origin because they can be deflected by magnetic fields, cosmic neutrinos detected by the IceCube Observatory can be traced back to their sources of origin. We will consider an active galactic nucleus (AGN) as a candidate source for a high-energy neutrino.This thesis examines the AGN WISEA J175051.31+105645.3 as a potential source for IceCube-220303A, a high-energy neutrino with a 78% probability of being astrophysical in origin. Using follow-up NuSTAR and Swift/XRT observations, WISEA J175051.31+105645.3 was the only viable source we found in IceCube-220303A’s uncertainty region. We used follow-up X-ray data to construct a multi-wavelength spectral energy distribution (SED) through which we calculated the AGN’s neutrino energy flux. This calculation yields the number of neutrinos we would expect to detect from the AGN in a given time period. We used this number to calculate the probability that IceCube-220303A was emitted by WISEA J175051.31+105645.3. Finding a statistically significant link between IceCube-220303A and WISEA J175051.31+105645.3 may help us better understand what processes can accelerate particles like cosmic rays to extreme energies and learn more about AGN.
Modulation of the stretch feedback pathway in the cardiac neuromuscular system of the American lobster, Homarus americanus
Date: 2024-01-01
Creator: Karin van Hassel
Access: Open access
- The cardiac ganglion (CG) is a central pattern generator, a neural network that, when activated, produces patterned motor outputs such as breathing and walking. The CG induces the heart contractions of the American lobster, Homarus americanus, making the lobster heart neurogenic. In the American lobster, the CG is made up of nine neurons: four premotor pacemaker neurons that send signals to five motor neurons, causing bursts of action potentials from the motor neurons. These bursts cause cardiac muscle contractions that vary in strength based on the burst duration, frequency, and pattern. The activity of the CG is modulated by feedback pathways and neuromodulators, allowing for flexibility in the CG’s motor output and appropriate responses to changes in the animal’s environment. Two feedback pathways modulate the CG motor output, the excitatory cardiac muscle stretch and inhibitory nitric oxide feedback pathways. Despite our knowledge of the modulation of the CG by feedback pathways and neuromodulators separately, little is known about how neuromodulators influence the sensory feedback response to cardiac muscle stretch. I found one neuromodulator to modulate each phase of the stretch response differently, one neuromodulator to generally not affect the stretch response, and three neuromodulators to suppress the stretch response. These results suggest neuromodulators can act to produce flexibility in a CPG’s motor output, allowing the system to respond appropriately to changes in an organism’s environment, and allow for variation in CPG responses to different stimuli.
Activation of Hydrogen by Sterically Modulated Coinage Metal Catalysts via Mutual Quenching of Hard/Soft Acid/Base Mismatches
Date: 2024-01-01
Creator: Zach Leibowitz
Access: Open access
- To mitigate the devastating environmental impacts of climate change in the coming decades, it is imperative that we replace the use of fossil fuels with renewable energy sources such as wind, solar, and hydroelectric. As these renewable energy sources are inherently intermittent, there exists a need for sustainable mechanisms to store renewable energy for later use. While the direct use of dihydrogen (H2) as a combustible fuel would allow for energy storage without the harmful release of carbon dioxide (CO2) upon combustion, the practicality of H2 as a synthetic fuel is limited by its low volumetric energy density. Combining sustainable H2 production (e.g. electrolysis using energy from renewable sources) with subsequent carbon fixation (e.g. the hydrogenation of CO2) represents a promising pathway to the sustainable production of high-density synthetic fuels. We hypothesize that such a process could be catalyzed by an IPr**-supported catalyst containing a hard/soft acid/base (HSAB) mismatch, with a polarizable coinage metal acting as a soft acid. As such, the aim of our project is the construction of a catalogue of IPr**-supported copper, silver, and gold catalysts that we anticipate will facilitate the heterolysis of dihydrogen and subsequent hydrogenation of CO2. In the present paper, we report the synthesis and characterization of an IPr**-silver complex which will serve as a precursor to many of our proposed HSAB mismatch catalysts and discuss next steps as we construct our catalogue of catalysts.
Democracy Promotion in U.S. Counterinsurgency: Tracing Post-War Security Sector Reconstruction in El Salvador and Iraq
Date: 2020-01-01
Creator: Emma Redington Lawry
Access: Open access
- Throughout the 21st century, certain facets of the democratic peace theory have informed American foreign policy, as policymakers credit democracy promotion with long-term stability and peace. In contrast, many political scientists have documented the often destabilizing and violent effects of democratization, particularly in underdeveloped states. How can we reconcile these tensions, and in what ways do they affect American foreign policy abroad? Under the lens of just war theory, or the doctrine of military ethics detailing the conditions under which it is morally acceptable to go to war, wage war and restore peace after war, this paper seeks to examine security sector reconstruction in post-counterinsurgency eras. In doing so, my analysis documents the effects of electoral processes on security and underscores the many difficulties of post-war rebuilding processes. In understanding these difficulties, I attempt to extract crucial lessons from the “best case” scenario of El Salvador and the “worst case” scenario of Iraq, both of which illuminate the fundamental tension between democratization and stability.
Solvent Effect on Excited State Proton Transfer Mechanism of 8-Amino-2-Naphthol
Date: 2021-01-01
Creator: Gabrielle Vandendries
Access: Open access
- Photoacids, compounds that undergo excited state proton transfer (ESPT), have been utilized in different solar energy and lithographic applications.1, 2 The addition of functional groups and solvent can both change the ESPT mechanism of photoacids. In this study, the effect of solvent on the ESPT mechanism was explored using a model diprotic photoacid, 8-amino-2-naphthol (8N2OH). The photochemistry of 8N2OH in water and common nonaqueous solvents, acetonitrile, tetrahydrofuran (THF), and methanol, were studied using UV/Vis absorption, steady-state emission, and time-correlated single photon counting (TCPSC) emission spectroscopy. The results were analyzed using the Kamlet-Taft parameters. It was found that the ESPT mechanism of the cation in water is different from the mechanism in acetonitrile and THF. In water the excited cation forms the zwitterion, i.e. the OH site undergoes ESPT, while in acetonitrile and THF, the excited cation forms the neutral species, i.e. the NH3+ site undergoes ESPT. No ESPT was observed for 8N2OH in methanol. The effect of solvent mixtures on photoacidity was also investigated using acetonitrile and water mixtures. The solvent effects were more subtle; the time-resolved emission measurements showed the greatest stabilization of the excited neutral 8N2OH species at 20/80% acetonitrile-water mixtures. Finally, the ability to extend the solvent studies to ionic liquids, 1-ethyl-3-methylimidazolium (Im) trifluromethanesulfonate (OTF), was demonstrated. The combined studies reveal that solvent plays a large role in determining the ESPT mechanism and stabilization of 8N2OH.
A Foray into the Camp: Human and Ecological Liberation in Contemporary Queer Conversion Therapy Literature
Date: 2021-01-01
Creator: Mitchel Jurasek
Access: Open access
- Through the analysis of two contemporary conversion therapy novels in North America, this project explores the intersections of biopolitics (specifically camp theory), queer theory, ecocriticism, and YA literature. Emily Danforth’s The Miseducation of Cameron Post and Nick White’s How to Survive a Summer are paired with scholars such as Gilles Deleuze, Felix Guattari, Joshua Whitehead, Greta Gaard, Hannah Arendt, Giorgio Agamben, Claudio Minca, Catriona Sandilands, Luce Irigaray, and Michael Marder to create a complex and intricate understanding of how ecologies impact queer youths’ experience in conversion therapy camps. The effect of such an intersectional and ecological understanding of queer becomings creates a foundation for further discovery and offers examples for current and future people to find mutual liberation with the ecologies we exist in.
Chambers of Reflection: Rousseau, Tocqueville, and Self-Government in the Digital Age
Date: 2020-01-01
Creator: John Sweeney
Access: Open access
- Jean-Jacques Rousseau and Alexis de Tocqueville each warn that the dominant cultures of their days may hinder the project of self-government. Against the backdrop of advancing Enlightenment philosophy, Rousseau writes that as social visibility increases relative to intimate connection, the drive for recognition corrupts self-love. Following the American and French revolutions, Tocqueville explores the democratic erosion of social hierarchies. He writes that a rise in individualism may obscure “self-interest well-understood”—the perspective gained through collaboration with others, thoughtful reflection, and reverence for truths that lie beyond the dictates of cursory instincts. In this project, I apply these political theories to the Digital Age. I explain how the distinction between the physical world and the digital realm has actualized Rousseau’s depiction of double men, “always appearing to relate everything to others and never relating anything except to themselves alone.” In the era of social distancing, technological evolution threatens to induce regression in the sociability and reflective agency that promote our capacity for self-government. Accordingly, I argue that Rousseau’s theory of corrupted drive for recognition and Tocqueville’s theory of individualism inform a new danger to political freedom: digital tribalism.
Genetic Analysis of Cellular Adhesion in Arabidopsis thaliana
Date: 2021-01-01
Creator: Andrew Close Bolender
Access: Open access
- Plant cell adhesion is mediated by the extracellular matrix (ECM) or cell wall and plays an important role in plant morphogenesis and development. The amount, modification, and cleavage of pectin in the cell wall are major contributors to the adhesive properties of the ECM. To gain a more complete picture of plant cell adhesion processes, Arabidopsis thaliana seedlings were previously mutagenized and screened for hypocotyl adhesion defects. Genomic sequencing of one plant exhibiting an adhesion defect, isolate 242, showed that two mutations, one in cellulose synthase (CesA1) and another in a sugar transporter, are candidates for the causative mutation. This thesis reports that CesA1 is necessary for proper plant cell adhesion, while the sugar transporter encoded at At4g32390 is not. Dark grown seedlings homozygous for mutations in CesA1 stain in ruthenium red, indicating atypical adhesion, while those homozygous for null mutations in At4g32390 do not. Previous study of another adhesion mutant revealed ELMO1, a Golgi protein necessary for plant cell adhesion, and four additional homologs ELMO2-5 in the A. thaliana genome. Two of these homologs, ELMO2 and ELMO3, fused to GFP, colocalized with mCherry-MEM1 markers in the Golgi, but not mCherry-NLM12 ER markers, indicating that ELMO2 and ELMO3 are also Golgi proteins.
Word Embedding Driven Concept Detection in Philosophical Corpora
Date: 2020-01-01
Creator: Dylan Hayton-Ruffner
Access: Open access
- During the course of research, scholars often explore large textual databases for segments of text relevant to their conceptual analyses. This study proposes, develops and evaluates two algorithms for automated concept detection in theoretical corpora: ACS and WMD retrieval. Both novel algorithms are compared to key word retrieval, using a test set from the Digital Ricoeur corpus tagged by scholarly experts. WMD retrieval outperforms key word search on the concept detection task. Thus, WMD retrieval is a promising tool for concept detection and information retrieval systems focused on theoretical corpora.